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Huge Bang Idea star Mayim Bialik reveals ‘nightmare’ response after taking weight-loss drug

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5 Jun 2026 20:19
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3 minutes reading



The Huge Bang Idea star Mayim Bialik has opened up about her ‘nightmare’ experiences utilizing GLP-1s, which left her with cramps, sneezing suits, and ‘explosive diarrhoea’.

The 50-year-old actress shot to fame when she was simply 14, enjoying the titular position in NBC’s Blossom, however is maybe finest recognized for taking part in Sheldon Cooper’s other-half Amy Farrah Fowler on The Huge Bang Idea.

Bialik says that she grew up ‘blissfully unaware’ of her weight, till her teenagers years when she was placed on treatment to ‘handle her moods’ that made her acquire weight.

“By my 40s, nonetheless actively working as an actress, I acquired a deep sense of disgrace round my physique,” she wrote in a chunk on The Free Press.

Mayim Bialik opened up her ‘nightmare’ expertise with the load loss drug (Black go well with Theo Wargo/Getty Photographs)

She went on to say that she gained ‘20 kilos’ after going by means of early menopause, however claimed that wasn’t the rationale she took the weightloss drug GLP-1.

“I went on a weight-loss drug as a result of a physician informed me it’d assist ease signs I’ve struggled with for mainly my total grownup life,” she wrote, revealing she was recognized with autoimmune situation Graves’ illness in her early 20s.

Bialik mentioned she was later recognized with Sjögren’s syndrome, dysautonomia, connective tissue illness, and mast cell activation syndrome all of which left her with a myriad of signs together with full-body rashes, extreme histamine reactions and crippling melancholy.

After being steered GLP-1 by three completely different medical doctors to assist handle her signs, Bialik mentioned she gave it a go, however revealed that taking the weight-loss treatment had been a ‘nightmare’.

“I took one shot of the bottom dose of an artificial GLP-1, and to say I had an hostile response can be considerably of an understatement,” she wrote.

Bialik as Amy in The Huge Bang Idea (Warner Bros)

“Explosive, uncontrollable diarrhoea. Sulfur burps so violent, they left me afraid to open my mouth in public. Sneezing assaults each time I attempted to eat or drink — which apparently has a reputation: snatiation.

“Cramping. Bloating. Full-body aching, as if I had the flu. And an incapability to maintain down even small sips of water with out sprinting to the toilet with but extra explosive diarrhea. Greater than thrice, I didn’t make it.”

GLP-1 has been hailed as a revolutionary drug and is taken by tens of millions of individuals throughout the globe to assist them drop some weight, together with celebrities like Jeremy Clarkson and Insurgent Wilson.

Nevertheless, Bialik mentioned that whereas ‘GLP-1s have helped individuals in severe want’, she needed to talk out about what can occur when ‘issues go fallacious’.

Within the piece, the mum-of-two mentioned she went again to her physician who confirmed that the side-effects have been attributable to the treatment and she or he finally determined to come back off it.

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