NFL Week 2 Schedule: Full Slate of Games, Times and Matchups
The 2025 NFL season is officially underway after an explosive opening weekend that featured record-setting scoring, a Super Bowl rematch, an international game in Australia, and several dramatic returns. Now the league shifts into Week 2 with a packed schedule highlighted by prime-time showdowns and key divisional rivalries.
Thursday Night Football: Bills vs. Lions Opens New Stadium Era
The week kicks off with a potential Super Bowl preview on Thursday Night Football. Josh Allen and the Buffalo Bills (1-0) host Jahmyr Gibbs and the Detroit Lions (1-0) in the inaugural regular-season game at the Bills’ new stadium. Both offenses enter the matchup riding high after Week 1 victories.
Sunday Early Window: Eight Games at 1 p.m. ET
Sunday’s early slate features eight contests, including several divisional battles:
- Minnesota Vikings at Chicago Bears – NFC North rivalry renewed
- Washington Commanders at Dallas Cowboys – High-stakes NFC East clash
- Additional early games rounding out the 1 p.m. ET window
Sunday Late Afternoon: Four Games at 4:05/4:25 p.m. ET
The late window showcases four matchups with playoff implications:
- Jacksonville Jaguars at Denver Broncos – AFC showdown between two of 2025’s top teams
- Pittsburgh Steelers at New England Patriots – Classic AFC rivalry
- Houston Texans at Cincinnati Bengals – Emerging AFC contenders collide
- One additional late-afternoon contest
Sunday Night Football: Chiefs Host Colts in AFC Heavyweight Bout
NBC’s Sunday Night Football delivers an AFC marquee matchup as Patrick Mahomes and the Kansas City Chiefs welcome Jonathan Taylor and the Indianapolis Colts to Arrowhead Stadium. Both teams enter 1-0 with championship aspirations.
Monday Night Football: Giants-Rams Cap Week 2
The week concludes with an NFC battle on Monday Night Football. Jaxson Dart and the New York Giants—fresh off a Sunday Night Football win in Week 1—travel west to face Matthew Stafford and the Los Angeles Rams, who are returning home after their season-opening game in Melbourne, Australia.
Week 2 at a Glance
| Day | Featured Matchup | Network/Time |
|---|---|---|
| Thursday | Detroit Lions at Buffalo Bills | Thursday Night Football (8:15 p.m. ET) |
| Sunday | 8 early games + 4 late games | 1:00 p.m. & 4:05/4:25 p.m. ET |
| Sunday Night | Indianapolis Colts at Kansas City Chiefs | NBC (8:20 p.m. ET) |
| Monday | New York Giants at Los Angeles Rams | Monday Night Football (8:15 p.m. ET) |
With five divisional games on the docket and multiple rematches of 2024 playoff teams, Week 2 offers an early look at the AFC and NFC hierarchy. Stay tuned for injury updates, weather reports, and betting lines as kickoff approaches.
